Figure 5.
(a) A model representing the microenvironment from pH 4.5 to
7.3, where FAD is in the neutral oxidized form and His447 is in
the imidazole form protonated at NE2. (b) A model representing
the microenvironment at pH 9.0, where the negative charge of the
imidazolate form of His447 is stabilized by interaction with
Asn321 and Asn323.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Chem Biol
(2006,
2,
259-264)
copyright 2006.
