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Figure 5.
Fig. 5. Three-way junction between IL-2, IL-2R , and
[c]. IL-2 (yellow
ribbon representation), IL-2R , and [c] (the
surfaces are colored as in Figs. 3 and 4) form a three-way
junction at the heart of the high-affinity IL-2 signaling
complex. The network of residues that mediate these contacts
(colored red) provides a compelling structural basis for
cooperativity in the IL-2/IL-2R complex assembly.
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