Figure 5 - full size

 

Figure 5.
Fig. 5. Three-way junction between IL-2, IL-2R , and [c]. IL-2 (yellow ribbon representation), IL-2R , and [c] (the surfaces are colored as in Figs. 3 and 4) form a three-way junction at the heart of the high-affinity IL-2 signaling complex. The network of residues that mediate these contacts (colored red) provides a compelling structural basis for cooperativity in the IL-2/IL-2R complex assembly.