Figure 5 - full size

 

Figure 5.
FIGURE 5. Structural similarity. A, stereo representation of the superposition of tyrosinase and structurally homologous proteins, potato catechol oxidase (Protein Data Bank code 1BT1) and octopus hemocyanin (Protein Data Bank code 1JS8). Red, blue, and green indicate the backbone traces of tyrosinase, catechol oxidase, and hemocyanin, respectively. The yellow sphere indicates the two copper ions in the catalytic center. To emphasize similarity, the C-terminal domain of hemocyanin is omitted from the figure. B, stereo view of the superposition of ORF378 and the SH2 domain in the growth factor-bound protein 2 (Protein Data Bank code 1GRI). Red and blue indicate the backbone trace of ORF378 and the SH2 domain in the growth factor-bound protein 2, respectively.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2006, 281, 8981-8990) copyright 2006.