Figure 5.
FIGURE 5. Interactions of helix 7 with the PTP1B core.
In the wild-type structure (Protein Data Bank code 1SUG; shown
in cyan), an extensive network of hydrogen bonds connects helix
7
to helix 3 and the loop between
strands 9 and 10. In
the S295F mutant (shown in yellow), helix 7 is repositioned and
partially disordered, with consequent disruption of this
extensive network of interactions. Only the hydrogen bond
between the side chains of Tyr^152 and Asn^193 is retained.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2006,
281,
5258-5266)
copyright 2006.
7 with the PTP1B core.
In the wild-type structure (Protein Data Bank code 1SUG; shown
in cyan), an extensive network of hydrogen bonds connects helix
9 and