Figure 5.
Figure 5 Structural model for release of DAD by Rho binding. (A)
Model of a complex of mDia[N] with Rho GTP
and the DCR, using the previous RhoC complex structure (Rose et
al, 2005b) and the DAD complex structure obtained here and the
superimposition shown in Figure 4B. (B) Details of the
electrostatic repulsion between DAD and Rho in a proposed
ternary mDia[N]-Rho-DAD complex; the steric clash on inserting
the next DAD residue, Thr1179, is indicated by a green circle.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Embo J
(2005,
24,
4176-4187)
copyright 2005.
GTP
and the DCR, using the previous RhoC complex structure (Rose et
al, 2005b) and the DAD complex structure obtained here and the
superimposition shown in Figure 4B. (B) Details of the
electrostatic repulsion between DAD and Rho in a proposed
ternary mDia[N]-Rho-DAD complex; the steric clash on inserting
the next DAD residue, Thr1179, is indicated by a green circle.