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Figure 5.
Figure 5. Binding of the pyrrolo-pyrimidine inhibitor
CGP77675 to the kinase domain of Src. (a) Stereo view of the
inhibitor binding pocket with Sim weighted electron density maps
of the refined complex of CGP77675 and the kinase domain of Src
at 2.3 Å resolution (light brown, 2mF[o] -dF[c], contoured
at 1s) and an omit map (dark brown, mF[o] -dF[c], contoured at
2s) prior to building inhibitor into the model. (b) Stereo view
of the inhibitor binding pocket: molecules A and B of the
asymmetric unit have been superimposed. They show the same basic
binding mode; the differences in the 4-hydroxy-piperidine-ethyl
substituent are well defined by electron density maps.
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