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Figure 5.
Figure 5. S5a flexible regions allow adaptable binding to
tetraubiquitin. In (a) K48-linked tetraubiquitin from a crystal
structure (PDB code 1TBE)39 binds each of the UIMs of S5a via
its two distal ubiquitin moieties. A snapshot of the two UIMs
contacting either (b) neighboring or (c) terminal ubiquitin
moieties is provided for K48-linked tetraubiquitin, in which the
ubiquitin subunits are not forced to contact each other. The
ubiquitin moieties are numbered sequentially according to the
position of a hypothetical protein substrate: Ub1 (colored red)
would be attached to a protein substrate via its G76. This
Figure was generated by using MOLSCRIPT.50
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