Figure 5.
Figure 5. The effect of botrocetin on the kinetics of the GPIb
-vWF-A1
tether bond. (a,b) Botrocetin does not enhance the cellular
on-rate for either the human or mouse GPIb -vWF-A1
tether bond as observed for the type 2B mutation I546V. An
enhancement in cellular on-rate is denoted as an increase in
tethering frequency of protein-coated beads. Data represent mean
s.d.
for three independent experiments. WT, wild type.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Mol Biol
(2005,
12,
152-159)
copyright 2005.
-vWF-A1
tether bond. (a,b) Botrocetin does not enhance the cellular
on-rate for either the human or mouse GPIb 
-vWF-A1
tether bond as observed for the type 2B mutation I546V. An
enhancement in cellular on-rate is denoted as an increase in
tethering frequency of protein-coated beads. Data represent mean
s.d.
for three independent experiments. WT, wild type.