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Figure 5.
Figure 5. Mutagenesis Data Mapped onto StructureThe
positions of substitutions that abolished (red) or decreased
(blue) pIgA binding to rabbit pIgR (Coyne et al., 1994) are
mapped onto the human pIgR D1 structure. A close-up of the CDR1
region is shown in the upper right, and the sequence of CDR1 in
human and rabbit pIgR D1 is shown in the lower right. Val29
(black), which is solvent exposed in the D1 structure, was
assumed to be buried and was therefore not substituted (Bakos et
al. 1993 and Coyne et al. 1994).
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