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Figure 5.
FIG. 5. Comparison of the N-terminal sub-domain of
CR[ColIIA] (shown in turquoise) and fibronectin type 1 (shown in
pink) domains. A, structural alignment of the N-terminal domain
of CR[CoIIIA] and the N-terminal domain of 1FBR (a
representative structure of the fibronectin type 1 domain) based
on the backbone atoms of 40 residues (r.m.s.d. = 2.0 Å).
Cysteines in the N-terminal domain of CR[CoIIIA] domain are
highlighted in black excluding Cys52, which is not conserved in
fibronectin domains but forms a disulfide bond to the second
domain in CR[CoIIIA]. B, multiple sequence alignment of the
N-terminal sub-domain of CR[ColIIA] and FN1 domain sequences
from fibronectin. For the CR[ColIIA] sequence, residues
Ala^31-Ile^67 are shown in the alignment.
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