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Figure 5.
Figure 5 Comparison with other PH domain structures. (A) Overlay
of the 3G ARNO PH domain (semitransparent) and PLC  PH
domain (PDB ID code: 1MAI), both in complex with Ins(1,4,5)P[3],
following superposition of C  atoms.
Ins(1,4,5)P[3]is depicted in red (3G ARNO) and yellow (PLC ).
(B) Schematic diagram illustrating the approximate rigid body
and torsion angle rotations that transform Ins(1,4,5)P[3] from
the orientation in the PLC PH
domain to that in the 3G ARNO PH domain. (C) Overlay of
Ins(1,4,5)P[3] bound to the 3G ARNO PH domain with the electron
density corresponding to inorganic sulfate ions from the
unliganded 3G Grp1 PH domain following superposition of C atoms.
The electron density is from  A
weighted F[o] -F[c] and 2F[o] -F[c] maps contoured at 3.0 and
1.2 ,
respectively. The maps were generated as in Figure 2C. (D)
Overlay of the 2G Grp1 PH domain (semitransparent) and the PKB
PH domain (PDB ID code: 1H10), both in complex with
Ins(1,3,4,5)P[4], following superposition of C atoms.
Ins(1,3,4,5)P[4] is depicted in yellow (2G Grp1) and green (PKB).
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