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Figure 6.
Figure 6. A Model of a Homologous Pairing Intermediate
Complex between Dmc1, ssDNA, and dsDNA(A) Schematic
representation of dsDNA passing through the central channel of
Dmc1. The N-terminal domain (colored yellow) may initially bind
to dsDNA, creating a bending stress that could cause the
dissociation of the ATPase domain (colored pink).(B) Ternary
complex formation by the Dmc1 double ring, ssDNA, and dsDNA
requires ATP. The search and the pairing of two homologous
sequences could take place at the center of the Dmc1 double
ring. The dsDNA is shown entering from one end of the stacked
ring. The ssDNA is shown passing through the cavity created by
the stacking of two Dmc1 rings.
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