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Figure 5.
FIG. 5. Comparison of the Mona/Gads SH3-HPK1 peptide
complex with other such structures. A, stereo view superposition
of peptides from three different SH3-peptide complexes. SH3
domains are omitted for clarity. The HPK1 is colored (complex
with Mona/Gads SH3C) in green, the Sos peptide (bound to Grb2
SH3N; 1GBQ [PDB]
.pdb) is colored in orange, and the UBPY (USP8) peptide (in
complex with Stam2 SH3; 1UJ0.pdb) is colored in yellow. Peptide
orientation is identical in all three cases with N termini
pointing up. B, detail of the interactions between the RXXK
motif within the HPK1 peptide and Mona/Gads SH3C. C, the
corresponding region from the Sos peptide-Grb2 SH3N complex
(1GBQ [PDB]
.pdb). For clarity, peptide residues are outlined by a light
gray underlay.
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