Figure 5.
FIG. 5. Superposition of unliganded A1, wild-type GpIb -A1 and
GpIb -M239V-A1-R543Q.
Rearrangement of the 1- 2 loop region of A1 is
highlighted. The 1- 2 loop region of
unliganded A1 (33)(shown in purple) adopts an intermediate
conformation between the closed conformation of 1- 2 in the
mutant complex (blue) and the open conformation of 1- 2 in the
wild-type complex (gold).
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2004,
279,
23327-23334)
copyright 2004.
-A1 and
GpIb 
2 loop region of A1 is
highlighted. The