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Figure 5.
Fig. 5. Determinants of specificity of TPO for c-Mpl.
Residues that are invariant within the TPO family but not
conserved in the EPO family are proposed to confer specificity
to the TPO-c-Mpl interaction. These residues fall into two
distinct clusters corresponding to the proposed high-affinity
(blue) and low-affinity (green) receptor interaction sites.
Residues that are invariant in the TPO/EPO family are shown in
black.
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