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Figure 6.
Figure 6. Missense Disease Mutations(A) Sequence
conservation of MTM1 and MTMR2 and the location of missense
disease mutations. The sequence of MTMR2 corresponding to the
crystal structure was aligned with MTM1. Regions of identity are
boxed and shaded. Arrows and ovals represent β strands and α
helices, respectively. Missense disease mutations are marked
with arrowheads.(B) Van der Waals surface space-filled model of
MTMR2. The view is the same as Figure 2A. The PH-GRAM domain is
shown in green, the phosphatase domain in blue, and the active
site motif (P loop) in yellow. Residues that are sites of
missense disease mutations are red and labeled when >10% solvent
accessible.(C) View corresponding to a 180° rotation around
a vertical axis with respect to Figure 6B. Solvent accessible
residues are indicated.
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