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Figure 5.
FIG. 5. Interactions between SOS/Ins6S and Fs1. A and B,
binding of SOS (A) and Ins6S (B) to Fs1. Sulfate groups from
these two heparin analogs are numbered, along with protein
residues involved in the interaction. C, superimposition of the
Fs1/SOS (ochre) and Fs1/Ins6S (blue) structures, showing the
relative positioning of sulfate groups in the binding site. D-F,
the interfaces between the heparin-binding region of one Fs1
molecule (blue) and the Kazal-like subdomain of one of its
symmetry-related counterparts (ochre) are depicted for each of
the three Fs1 structures. Residues involved in protein-protein
and additional protein-ligand contacts are labeled, as are the
sulfate groups interacting with the symmetry-related Fs1
molecules.
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