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Figure 5.
FIG. 5. Antithrombin RCL conformation and modeled
interaction with thrombin. a, superposition, in stereo, of the
conformations of P5-P5' residues of  [1]PI Pittsburgh from
its noncovalent complex with S195A trypsin and of
pentasacharide-activated antithrombin from a structure of the
heterodimer (orange) (Protein Data Bank code 1AZX [PDB]
). These RCLs are aligned such that the P1 residues have the
same horizontal position. The view is rotated 90°
anticlockwise relative to Fig. 1b. b, stereo representation of
the P5-P5' residues of antithrombin from the x-ray structure of
antithrombin heterodimer docked into the thrombin structure
found in the noncovalent complex of S195A thrombin with heparin
cofactor II, showing inappropriate positioning relative to the
catalytic triad and unfavorable interactions with surface loops.
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