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Figure 5.
FIG. 5. Model of factor IXa. The epidermal growth factor
(green) and serine protease (yellow) domains of factor IXa (42)
are shown connected to the IXGD1-46 structure (white), using
factor VIIa structure (17) as a reference model. The bound Mg2^+
and Ca^2^+ ions are drawn as orange and blue spheres,
respectively. D-Phe-Pro-Arg-chloromethylketone, which is bound
to the active site, is shown as a red stick model. The
phospholipid membrane surface is shown by a yellow line.
Hydrophobic residues (yellow), basic residues (purple) and Mg2^+
ion (Mg-1) of GD1-46 are possible candidates for membrane
binding.
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