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Figure 5.
Figure 5. Stereo view of the surface plots of the
hydrophobic inhibitor binding sites. (a) The DIC19 binding
region in calcium-bound DVI. DIC19, represented as a helical
segment, yellow in color, clearly displays its amphipathic
nature with its bulky hydrophobic side-chains buried deep into
DVI and polar residues exposed to the solvent (side-chains
removed for clarity). (b) Bulky hydrophobic ring of the
inhibitor PD150606 and Phe610 of DIC19 occupy the same region of
DVI. However, the hydrophobic region that accommodates these
inhibitor molecules seems to be flexible enough, varying in size
to accommodate different sized inhibitors. c) View of the
inhibitor binding regions in the calcium-free DVI structure.
DIC19 is positioned in the same place, as in previous Figures,
indicating the narrowness of the hydrophobic region.
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