|
Figure 5.
Fig. 5. Schematic drawing of the closed and opened conformation
of a ClC chloride channel. In the closed conformation, the
ion-binding sites S[int] and S[cen] are occupied by chloride
ions, and the ion-binding site S[ext] is occupied by the side
chain of Glu148. In the opened conformation, the side chain of
Glu148 has moved out of binding site S[ext] into the
extracellular vestibule. S[ext] is occupied by a third chloride
ion. Chloride ions are shown as red spheres, the Glu148 side
chain is colored red, and hydrogen bonds are drawn as dashed
lines.
|
