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Figure 5.
Figure 5. Stereo Diagrams of the ATP Binding Sites(A)
Aurora-A ATP binding site. Carbon atoms, gray; oxygen atoms,
red; nitrogen atoms, blue; phosphorus atoms, green. Water
molecules and Mg2+ ions are represented by red and blue crosses,
respectively.(B) FAK ATP binding site(C) EphA2 ATP binding site.
The representative 2F[o] - F[c] electron density around the ATP
has been computed at 1.9, 1.6, and 2.3 Å for Aurora-A, FAK, and
EphA2, respectively. The density is contoured at 1 s (blue) and
4 s (red). The side chains of the residues that distinguish the
structures of the ATP binding sites are shown with the dotted
van der Waals surface. Hydrogen bonds between the protein and
ATP are shown as dashed lines. The figure was prepared with Xfit
[56].
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