|
Figure 5.
Fig. 5. The solvent-accessible surface of the bound
conformation of UCN-01 (purple) is shown with the
solvent-accessible surface of Chk1 (green mesh) in the
Chk1·UCN-01 complex. The shape complementarity between
this rigid inhibitor and the binding site is very high, and the
large amount of non-polar buried surface area in the complex
provides the energy for a very strong interaction.
|
