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Figure 5.
Figure 5. Solid-surface representation of HPK. A consensus
substrate peptide (SSYYSG), shown as ball-and-stick, was
positioned, as in model structure 2PSA,[18.] in the specificity
pocket of HPK in an attempt to show the necessary changes for
substrate/serpin binding. In the right-hand picture, the
surfaces corresponding to the kallikrein loop (Leu95A-Ser100)
and to residues Trp215 to Cys220 have been removed, as well as
the catalytic triad residues, which are shown as ball-and-stick
and labelled red. The picture was drawn with GRASP. [53.]
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