|
Figure 5.
Fig. 5. Relaxed stereo ribbon diagrams of hK6 (top
panel), bovine trypsin (1CE5; middle panel), and mouse glandular
kallikrein 13 (mK13) (1AO5; lower panel). Orientation is
intended to show the active site cleft with locations of
catalytic triad (His57, Asp102, and Ser195), S1 site (Asp192),
and bound benzamidine inhibitor (if present). Also indicated are
the locations of the autolysis sites in hK6 and bovine trypsin.
The two canonical autolysis sites in the mouse kallikreins are
indicated using the structure of mK13. Also shown are the
locations of the loop regions 92-102 (blue), 141-152 (magenta),
and 172-178 (green) that border the active site.
|
