Figure 5.
Figure 5 Comparison of dynamin A Phe50 and Ras Phe28. Dynamin A
is colored in orange and Ras in green. GDP is only shown for
Ras. Gly47 at the end of helix 1
allows the switch I loop to take off at a different angle in
dynamin A than in Ras, which has no glycine at the equivalent
position. In dynamin A, Phe50 is buried by hydrophobic residues
of the -sheet
(not shown) instead of stabilizing the base as Ras Phe28 does.
The position of the Ras G5 motif (145SAK147) and of dynamin A
Asn238 and Arg 239 is also shown.
The above figure is reprinted
from an Open Access publication published by Macmillan Publishers Ltd:
EMBO J
(2001,
20,
5813-5821)
copyright 2001.
1
allows the switch I loop to take off at a different angle in
dynamin A than in Ras, which has no glycine at the equivalent
position. In dynamin A, Phe50 is buried by hydrophobic residues
of the 
-sheet
(not shown) instead of stabilizing the base as Ras Phe28 does.
The position of the Ras G5 motif (145SAK147) and of dynamin A
Asn238 and Arg 239 is also shown.