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Figure 5.
Figure 5 Comparison of the A- and B-view. In the A-view (A), the
interface appears to be more narrow than in the corresponding
B-view (B) due to the upward shift of the loop containing the
'lid' region, which has been clarified by including side chains
of residues 90, 93, 96 and 104. Notably, B-His95 approaches the
pyrophosphate to within hydrogen-bonding distance in the A-view,
while A-Tyr93 plays this role in the B-view. Arg47 shows a
difference in side chain conformation in the two views. Helices
2 and 3 are shifted outwards in the B-monomer by  3
Å as compared with the A-monomer.
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