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Figure 5.
Figure 5. Pathogenic missense mutations in the dystrophin
ABD. (a) Stereoview of the environment of Leu54. (b) Stereoview
of the 2F[o]-F[c] electron-density map in the region of Leu54.
The electron-density map is contoured at 1.0s. (c) Stereoview of
the environment of Ala168, Ala171 and Tyr231. The mutated
residues are coloured red, with neighbouring hydrophobic
sidechains coloured green. (d) Schematic representation of the
dystrophin ABD sequence. The upper representation shows the
actin-binding and mutation sites and the lower shows the exon
boundaries.
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