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Figure 5.
Figure 5. Binding of A771726 in the hydrophobic channel of
human DHODH. (a) Stereoview of the binding interactions of
A771726. Ligands are shown in ball-and-stick representation, and
residues interacting with A771726 are represented by thin
sticks. Hydrogen bonds are shown as dashed black lines. (b) A
2F[o]-F[c ]electron-density map of A771726, FMN and orotate
contoured at 1.2s (1.8 Å). Ligands and selected DHODH residues
in the vicinity are shown in ball-and-stick representation. This
figure was prepared with MOLSCRIPT [34].
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