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Figure 5.
Figure 5. Inhibitor binding to the active site of human
sNEP. (a) Stereo view of the active site inhibited by
phosphoramidon, green. Hydrogen bonds and ionic interactions are
indicated by broken lines, a-helices are shown as cylinders,
b-strands are represented by arrows: catalytic domain, violet;
the smaller domain 2, blue; the three interdomain linker
fragments, cyan. The zinc ion is shown in yellow. (b) Molecular
surface of the phosphoramidon recognition site colored by
electrostatic potential: positive, blue; negative, red.
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