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Figure 5.
Figure 5. Stereo plot of the hypothetical docking complex of the catalytic domain (white connections) and kringle
2 (yellow connections; De Vos et al., 1992) in the covalent two-domain t-PA variant. The domains are superimposed
with a blue (catalytic domain) and a green Connolly surface (kringle 2 domain). This view is approximately rotated
135° from the standard orientation around a horizontal axis, so that the active site is now pointing to the east/back.
Charged side-chains of catalytic domain residues presumably involved in fibrin binding, and kringle 2 residues forming
the lysine binding site are labeled (chymotrypsinogen and kringle nomenclature). The plot was made with MAIN (Turk,
1992).
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