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Figure 4.
Molecular details of the harmonin NPDZ1 and Sans SAM-PBM
interaction. (A and B) The combined surface charge
representation (NPDZ1) and the stick-ribbon model (SAM-PBM)
showing the interaction interface between harmonin NPDZ1 and
Sans SAM-PBM. The binding interface between the NPDZ1 and Sans
PBM is better viewed in (A), whereas the binding interface
between the NPDZ1 and Sans SAM is optimally depicted in (B). (C
and D) Stereo views showing the detailed interactions between
harmonin PDZ1 and Sans PBM (C), and between PDZ1 and Sans SAM
(D). The hydrogen bonds and salt bridges involved in the
interfaces are indicated as Dashed Lines. (E) A schematic
cartoon diagram summarizing the three different binding modes of
PDZ domains.
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