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Figure 4.
The structures of kinase domains of (A) wt-FGFR1 (PDB ID:
3KY2), (B) FGFR1-RE mutant (PDB ID: 3KXX), and (C) activated
FGFR1 (FGFR1-3P) (PDB ID: 3GQI) in a simplified cartoon (Upper)
and in a ribbon diagram (Below). The catalytic loop is shown in
yellow, and the activation loop in green, helix αC is depicted
as a cylinder in the cartoon. Phosphotyrosines are colored in
red in the cartoon and in stick representation in the ribbon
diagram. (D) Ribbon diagrams of kinase insert loops of FGFR1,
FGFR1-RE, and FGFR1-3P are in green, cyan, and blue,
respectively. Side chains of R576, R577 and R577E are shown in
stick representation. (E) Superposition of kinase insert regions
of FGFR1 (Green), FGFR1-RE (Cyan), and FGFR1-3P (Blue) revealing
multiple conformations of the kinase insert regions in the three
structures.
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