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Figure 4.
(a) The highly p110δ-selective compound AS15 does not open
the specificity pocket and makes extensive use of a hydrophobic
patch between Trp760, Thr750 and Met752 adjacent to the
adenine-binding pocket. The 2mF[o] – DF[c] contouring level is
1σ. (b) Chemical structures of AS15 and PIK-39. (c)
Superposition of AS15 and PIK-39 to demonstrate their different
modes of binding within the active site of p110δ.
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