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Figure 4.
Fig. 4. Binding modes of the allosteric modulators (a) CTZ,
(b) NS1493, (c) NS5206, and (d) NS5217 in iGluR2 S1S2J-N754S. An
F[o] − F[c] omit electron density map (green; contoured at 3
σ), a final 2F[o] − F[c] electron density map (light blue;
contoured at 1 σ), and potential hydrogen-bonding interactions
within 3.2 Å (broken lines) are shown. Oxygen atoms are
colored red, nitrogen atoms are colored blue, and sulfur atoms
are colored yellow. Water molecules are shown as red spheres.
The chemical structures of the compounds are shown in Fig. 1.
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