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Figure 4.
Structural examination of wobble pairing with
N^2,N^2-Me[2]G-modified DNA in Dpo4.A, overall structure of DNA
and corresponding electron density observed in the active site
of DMG-2 are shown. The orientation of bases observed in
molecule A (B) and molecule B (C) of the DMG-2 structure is
shown. D, overall structure of DNA and corresponding electron
density observed in the active site of DMG-2 are shown. The
orientation of bases observed in molecule A (E) and molecule B
(F) of the DMG-2 structure is shown. In all panels, the
3F[o][]− 2F[c] map (gray mesh) for DNA bound in the DMG-2
structure is shown contoured to 1σ level (gray mesh) with the
F[o][]− F[c] difference maps shown contoured to 3σ and −3σ
for positive (red mesh) and negative (green mesh) density,
respectively.
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