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Figure 4.
Figure 4. Similarity of the Grb2SH3C-Gab2b Complex with
Mona/GadsSH3C in Complex with SLP-76 and HPK1
(A) Alignment
of canonical RxxK motifs and structural superposition of the
three peptides from Gab2b, SLP-76, and HPK1 at the bound
conformations (based on SH3 domain superposition). Electrostatic
potential surface representation of (B) Grb2SH3C with Gab2b and
Mona/GadsSH3C with (C) SLP-76 and (D) HPK1 peptide bound. Boxed
regions in (B), (C), and (D) define the docking position of the
RxxK motif on the SH3 domain surface and close-up views of these
in atomic detail are provided in panels (E), (F), and (G),
respectively.
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