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Figure 4.
Figure 4. Residues Involved in the Formation of Interdomain
Interfaces
(A and B) Residues involved in interdomain
contacts were identified using the program Contact in the CCP4
program suite (CCP4, 1994), with a distance limit of 4 Å.
Hyb domain residues at the cbEGF9-hyb2 interface (A) or
hyb2-cbEGF10 interface (B) are indicated by magenta spheres and
interacting cbEGF residues are indicated by green spheres.
(C) An alignment of the hyb2 and TB4 domains shows similarities
of the regions involved in interactions with either the
N-terminal (red) or C-terminal (cyan) cbEGFs. Domains were
aligned using Clustal W 2.0 (Larkin et al., 2007), and cysteines
are highlighted in yellow.
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