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Figure 4.
Topology diagram of the TPP1 structure showing the prosegment
(Ser^20-Ser^180) and the catalytic domain
(His^197-Pro^563).α-Helices are labeled α and are represented
by cylinders, and β-strands are labeled β and represented by
arrows. Residues that are involved in the catalytic mechanism
are marked by red letters; the 6 cysteine residues that form
disulfide bridges are colored yellow on black background, and
the asparagine residues that carry N-linked oligosaccharides are
highlighted by a turquoise background. No density could be
observed for a possible glycosylation at Asn^222 (highlighted
with gray background). The linker region (Ser^181-Leu^196) was
poorly defined (gray letters). The first amino acid R of the
purification tag RSHHHHHH is displayed in gray.
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