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Figure 4.
Repositioning of Lys^309 in the structure of DNA pol ι with
N^2-ethyl-Gua in the syn configuration. A, the Lys^309 side
chain in DNA pol ι in complex with N^2-ethyl-Gua (green) in the
syn configuration shifts ∼9Å relative to the position of
Lys^309 in DNA pol ι complexed with syn Gua (PDB code 2ALZ,
magenta). B, with N^2-ethyl-Gua in the anti conformation (blue)
Lys^309 remains in a similar position relative to the Lys^309 in
the DNA pol ι·Gua complex (PDB code 2FLP, yellow).
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