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Figure 4.
Fig. 4. Architecture of ACE1. (A) ACE1 containing proteins are
shown as cylinders and sheets. Crowns are shown in blue, trunks
in orange, tails in green, and other domains in gray. Modules
with predicted structures are shown half-transparent. [PDB codes
are 2QX5 for Nic96; 3BG1, Nup145C; 3CQC, Nup107 (Nup84 homolog);
and 2PM6, Sec31] (B) Cartoons illustrating the similarity and
modular nature of the ACE1 element. The N-terminal elaborations
are, for Nic96, a coiled-coil domain that interacts with the
Nsp1 complex; for Nup85, the Seh1-interacting insertion blade;
for Nup145C, the Sec13-interacting insertion blade preceded by
an autocatalytic cleavage domain and Nup145N; and, for Sec31,
the Sec13-interacting insertion blade is preceded by its own
N-terminal seven-bladed β propeller. Sec31 has a unique
proline-rich insertion C-terminal to its trunk module followed
by a conserved region predicted to be  -helical.
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