Figure 4 - full size

 

Figure 4.
Superposition of WDR5 bound to the MLL1 Win peptide (yellow) with that of WDR5 bound to an unmodified histone H3 peptide (white) (PDB code 2CO0, Ref. 17), showing only the bound peptides. Residue names for the MLL1 Win peptide are shown in red, and residue names for the histone H3 peptide are shown in blue. The superposition minimizes the differences between Cα atoms of WDR5 residues between structures.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2008, 283, 32158-32161) copyright 2008.