Figure 4 - full size

Figure 4. (a) The surface projections of the hydrophobic spine that assembled during ABL kinase activation in ABL-ADP conformation (shown in blue; PDB 2G2I). The gatekeeper residue, Thr334, is shown as an orange surface. (b) The surface projections of the dismantled hydrophobic spine in the inactive kinase conformation of ABL–imatinib (PDB 1OPJ). Imatinib binds to the inactive kinase which is stabilized by the DFG-out conformation caused by dismantling of the hydrophobic spine.

The above figure is reprinted from an Open Access publication published by Macmillan Publishers Ltd: Nat Struct Biol (2008, 15, 1109-1118) copyright 2008.