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Figure 4.
Figure 4: A double-headed mechanism for EGFR inhibition by MIG6.
a, A co-transfection experiment showing that EGFR(activator)
can activate EGFR(activatable), and that MIG6 can inhibit this
activation. b, Co-transfection experiments showing that
full-length EGFR containing the L834R/V924R double mutation only
shows autophosphorylation when co-transfected with
EGFR(activator). Co-transfection combinations in a and b are
represented by the cartoons in the respective lower panels, for
clarity. The I682Q, D813N, L834R and V924R mutations are denoted
in the cartoons by a circle, diamond, star and triangle,
respectively. c, A schematic diagram showing the double-headed
mechanism for EGFR inhibition by MIG6 involving both segment 1
and segment 2.
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