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Figure 4.
Figure 4. Stereo Views of Pocket 2 Comparing Superpositioned
Kme2-Bound Wild-Type and Mutant L3MBTL1 Complexes
(A–D)
The wild-type L3MBTL1 complex with bound Kme2 is shown in beige
(A–D). The D355N mutant complex is shown in light blue (A),
the D355A mutant is shown in dark blue (B), the N358Q mutant is
shown in light green (C), and the N358A mutant is shown in dark
green (D). Kme2 was not detected in pocket 2 for complexes with
D355N (A), D355A (B), N358Q (C), and N358A (D).
Superpositioning is based on least-squares fitting of Cα atoms
within the second MBT module (349–416) of L3MBTL1.
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