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Figure 4.
Figure 4. Interactions between Mad2 and p31^comet
(A)
Ribbon diagrams of the Mad2-p31^comet complex. Two different
views are shown to provide a clearer perspective of the
Mad2-p31^comet interface. Helix αC in Mad2 is colored cyan to
highlight its central role in establishing interactions between
Mad2 and p31^comet. Three main patches of interactions at the
Mad2-p31^comet interface are labeled and circled with red dashed
lines.
(B–D) Interactions between Mad2 and p31^comet. The
side chains of contacting residues are shown as sticks. Nitrogen
and oxygen atoms are colored blue and red, respectively. Mad2
carbons are colored yellow and p31^comet carbons are colored
gray and labeled in italics. The tightly bound water molecules
are drawn as red spheres in (C).
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