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Figure 4.
FIGURE 4. Structural analysis of the catalytic cleft. A,
accessible surface of molecules A (white-blue-red) and B
(green-blue-red) in the asymmetric unit with
MeOSuc-Ala-Ala-Pro-Ala-CMK shown for molecule A. B,
semitransparent surface representation of the catalytic cleft of
HAM2. The stick model in color-by-atom denotes
MeOSuc-Ala-Ala-Pro-Ala-CMK bound to HAM2.
Suc-Ala-Ala-Pro-Phe-CMK (magenta), covalently bound to the
crystal structure of human chymase (37), is superimposed onto
the HAM2 structure. Molecular figures were prepared with PyMOL
(DeLano Scientific LLC, www.pymol.org).
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