|
Figure 5.
Fig. 5. Structural flexibility within Vps4. (a)
Superimposition of the four independently determined Vps4
structures in the current study. The three molecules (ADP-bound)
in the asymmetric unit of the P2[1]2[1]2[1] space group are
colored white, cyan, and red, respectively. The one molecule
(nucleotide-free) in the asymmetric unit of the P6[5]22 space
group is colored yellow. The magnitude of the en bloc motions
between the large AAA subdomain and small AAA subdomain and
between the small AAA subdomain and the β domain is illustrated
schematically. (b) Two potential hinge regions within Vps4
structure. The conserved proline residues in the hinge regions
are shown as spheres and highlighted in brown.
|
