|
Figure 4.
Fig. 4. Stick model of the modeled substrate
Glu-Ala-Leu-Tyr-Leu-Val, the catalytic triad and the backbone of
Gly^193, Ser^195, and Gly^216 of hK7[I] in stereo, including
hydrogen bonds as dotted lines. The S1 pocket is depicted as
transparent green surface according to volume calculations with
VOIDOO (41). The specificity for P1 Tyr is most likely conferred
by Asn^189 via hydrogen bonds from the carboxamide side chain to
an interconnecting water molecule and to the Tyr OH group,
respectively.
|
