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Figure 4.
Figure 4. The Lipopeptide-Binding Site of the Human TLR1-TLR2
Complex
(A) TLR1 and TLR2 residues involved in Pam[3]CSK[4]
binding are drawn in green and blue, respectively. The hydrogen
bonds are shown by broken red lines. Carbons, nitrogens,
oxygens, and a sulfur of the Pam[3]CSK[4] are colored in orange,
blue, red, and green, respectively. The H3 helix is drawn as a
coil for clarity. I319' of TLR1 is hidden behind the H3′
helix.
(B) Chemical structure of Pam[3]CSK[4.] Residues
interacting with Pam[3]CSK[4] are labeled. Hydrogen bonds are
drawn with broken red lines.
(C) The shape of the
Pam[3]CSK[4]-binding pocket is shown in mesh. Molecular surfaces
that belong to TLR1 and TLR2 are drawn in green and blue,
respectively. Pam[3]CSK[4] is shown as a space-filling model.
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